Drug Metabolism & Pharmacokinetics And Population PK/PD Modelling
Sub-optimal Drug Metabolism and Pharmacokinetics (DMPK) property is one of the leading causes behind the failure of new chemical entities (NCEs) during early clinical trials. Likelihood of a successful NCE demands a balance of optimised DMPK parameters and minimised drug-drug interaction (DDI) risks. DMPK studies are considered as an important phase within drug discovery and development for the selection of optimal drug candidates.
Optimisation of disease prevention along with treatment strategies by considering various factors leading to inter-individual variability advances precision medicine and dosing. Several clinical tools are available to interpret genotypic and phenotypic characteristics of an individual to design a personalised dosage regimen. Population Pharmacokinetics/Pharmacodynamics (PopPK/PD) modelling is such a tool used in the drug development process and it provides the association between dose, concentration and response before NDA approval and the subsequent launch of the drugs.
Furthermore, it promotes precision dosing in various approaches including covariate centred priori dosing and therapeutic drug monitoring (TDM) centered posteriori dosing. PopPK/PD modelling applies nonlinear mixed effects modelling (NONMEM), one of the widely used statistical software methodologies to characterise and interpret sources contributing to PK/PD variability.
Objectives
- To introduce DMPK and PopPK/PD and their role in drug optimisation and dosing individualisation in drug discovery and development.
- To provide hands-on training on:
– in vitro metabolic stability & CYP450 inhibition studies.
– dosage regimen design in therapeutic drug monitoring.
– PopPK/PD data analysis using R & NONMEM software programs
KEYNOTE SPEAKERS
- Prof Yuen Kah Hay
School of Pharmaceutical Sciences, Universiti Sains Malaysia - A/Prof Surulivelrajan Mallayasamy
Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University - Prof Ong Chin Eng
Associate Dean, School of Pharmacy, International Medical University - Dr Murugesh Kandasamy
Senior Lecturer, School of Pharmacy, International Medical University - Dr Hira Chaudry
Acting Head, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University
Registration Fee |
|
| Regular | RM1500 |
| IMU Alumni / Student (Non-IMU) | RM1050 |
| Student (IMU) | RM750 |
- Any cancellation of registration must be made in writing to the Secretariat of Workshop on Drug Metabolism & Pharmacokinetics and Population PK/PD Modelling.
- There will be a full refund of registration fee for cancellation made by 8 August 2019.
- There will be a 50% refund of registration fee for cancellation made before 8 September 2019.
- There will be a 30% refund of registration fee for cancellation made before 23 September 2019.
- There will be no refund of registration fee for cancellations made after 23 September 2019.
- The Organiser reserves the right to cancel or change the topic of the programme, if for whatever reasons beyond its control, the programme cannot be held as scheduled or the topics need to be altered.
DECLARATION AND AUTHORISATION
- I confirm that the above information is correct and I will inform IMU when there is any change to this information.
- I have read, understood and consent to the processing of my personal data as set out in the enclosed Privacy Notice.
DISCLAIMER
The organiser reserves the right to make such alterations to the programmes as circumstances dictate and will not accept responsibility for any errors, omissions or changes made to the speakers’ information. The views and opinions expressed by the speakers at this workshop are not necessarily the views and opinions of the organiser.
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